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Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.
Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Nichenko AS, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Brisendine MH, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Desjardins EM, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z.. Bar-On YM, et al. N Engl J Med. 2021 Sep 15. doi: 10.1056/NEJMoa2114255. Online ahead of print. N Engl J Med. 2021. PMID: 34525275. Free PMC article.
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Empagliflozin in Heart Failure with a Preserved Ejection Fraction.
Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Piña IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Preserved Trial Investigators.. Geng Q, et al. PLoS Pathog. 2021 Sep 7;17(9):e1009897. doi: 10.1371/journal.ppat.1009897. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34492082. N Engl J Med. 2021 Sep 15;385(14):10.1056/NEJMc2113394#sa1. doi: 10.1056/NEJMc2113394. Online ahead of print. N Engl J Med. 2021. PMID: 34525283 No abstract available..
A body map of somatic mutagenesis in morphologically normal human tissues.
Li R, Di L, Li J, Fan W, Liu Y, Guo W, Liu W, Liu L, Li Q, Chen L, Chen Y, Miao C, Liu H, Wang Y, Ma Y, Xu D, Lin D, Huang Y, Wang J, Bai F, Wu C. Li R, et al.

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